The Effect of Psychedelics on the Brain

My first goal was to discover whether the use of of psychedelic mushrooms would allow me to tap into a more effective and happier side of myself. And if so, what were the risks mail order shrooms involved?

My journey to better understand the effects of microdosing led me through the labyrinth of data on psychedelics research.

Key terms and definitions

Psilocybin — The psychoactive ingredient in ‘magic mushrooms’, or ‘shrooms’. It is converted to psilocin, enabling it to cross the blood-brain barrier. Structurally similar to the brain’s naturally occurring neurotransmitter serotonin, the hallucinogenic effects of this substance

LSD — Short for lysergic acid diethylamide, and more commonly known as ‘acid’. The effects of a typical dose (100ug) of this substance takes  to subside.

MDMA — Also known as ‘ecstasy’, ‘E’, or ‘Molly’, the effects of this drug last  Pilot studies have shown that  no longer met the criteria for PTSD.

DMT — Often regarded as the ‘for its ability to bring spiritually profound experiences. It is the active ingredient found in the ceremonial South American brew known as  and not to be confused with 5-MeO-DMT.

Hallucinogen — A class of substances that includes psychedelics, along with . Despite what the name would suggest, not all users experience visual hallucinations when under the influence (case in point: yours truly).

Trip (noun) / tripping (verb) — commonly used terms referring to any experience of being under the influence of psychoactive substances. However, the term is usually reserved for moderate or higher dose experiences.

Set and setting — A phrase coined by psychedelic pioneer  to describe the conditions of a trip, which can affect the quality and safety of the experience. Leary defines set as the “preparation of the individual, including his personality structure and his mood at the time.” Setting is “physical — the weather, the room’s atmosphere; social — feelings of persons present towards one another; and cultural — prevailing views as to what is real.”



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